Evidence library
Oxalobacter formigenes research summary
A concise, balanced map of the organism biology, human association data, controlled colonization research, and mixed clinical trial results.
Controlled human research
Inducing Oxalobacter formigenes Colonization Reduces Urinary Oxalate in Healthy Adults
Fargue et al., Kidney International Reports, 2025. PMID: 40485679.
Proof-of-concept healthy-adult study with controlled diet conditions.
Established biology Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist Daniel et al., Applied and Environmental Microbiology, 2021. PMID: 34190610.Review of organism biology, culture considerations, and oxalate metabolism.
Human association Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones Kaufman et al., Journal of the American Society of Nephrology, 2008. PMID: 18322162.Case-control association study in recurrent calcium oxalate stone formers.
Mixed clinical evidence Primary hyperoxaluria trials of orally administered Oxalobacter formigenes Hoppe, Milliner, Ariceta and collaborators, 2011-2023.Generally tolerated, but primary efficacy endpoints were mixed or not statistically significant.
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Evidence status
The strongest evidence here is for organism biology and oxalate metabolism. Human association and controlled colonization findings are important, but they should not be read as disease-treatment claims.
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